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Inhibition of Trx1 and Grx1 by preheated APR-246 is thiol-dependent and reversible To further study the reversibility of preheated APR-246-mediated inhibition of Trx1 and Grx1, we assessed the effect on the thiols in the two proteins

In recent years, there has been a significant increase in the number of patients being prescribed glucagon-like peptide-1 receptor agonists (GLP-1 RAs), a class of medications used to manage both type 2 diabetes and obesity ( 1 4 )