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Clinical trials have demonstrated average weight loss of approximately 15% with semaglutide 2.4 mg and up to 22% with tirzepatide 15 mg, though individual results vary considerably

23, 36 Hypoxia induces a HIF-1 -dependent accumulation of lipid droplets and decreased FAO in tumor cells, whereas the hypoxia-reoxygenation leads to increased FAO in MCF-7 breast cancer cells, thereby providing reduced power to protect against accumulation of ROS

However, semaglutide costs less (compounded: $199 vs $349/month), has proven cardiovascular benefits, and longer safety track record

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