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The immunological consequences of chitosan nanoparticle administration including complement activation, cytokine release and potential for adaptive immune responses upon repeated dosing have been examined superficially in most studies, yet these factors could profoundly influence both safety and efficacy in clinical translation, particularly for systems incorporating bacterial components or when used in combination with immune checkpoint inhibitors that are increasingly part of standard breast cancer therapy [205]
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Protection from hypertension in mice by the Mediterranean diet is mediated by nitro fatty acid inhibition of soluble epoxide hydrolase
