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LIFT-AD Trial: Phase 2/3 Termination (September 2024) Despite the ACT-AD disappointment, Athira advanced to a larger phase 2/3 trial called LIFT-AD

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Pregnancy and breastfeeding are stopping points: concentrated methyl-donor combinations are not well studied in pregnancy, and guidance is to avoid Lipo-C unless a clinician judges maternal benefit to outweigh theoretical risk under obstetric supervision

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However, women who are pregnant or breastfeeding should avoid supplementation unless specifically advised by their doctor due to insufficient safety data in these groups

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This can also provide a blueprint for treatment of other behavioral addictions

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However, a single application CP is impractical, its mechanical properties are poor, its rigid structure makes it highly intolerant, and it is highly sensitive to moisture and air (Acosta et al., 2022)

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