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The brain-access hypothesis and why it is contested One influential hypothesis for making sense of these mixed results, advanced by Christian Holscher, proposes that neuroprotective efficacy tracks a compounds ability to reach the brain
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The FDA found no clinical studies or publicly available human exposure data for administered MOTS-c, no adequate toxicology, uncertain characterisation and unresolved immunogenicity.[6] The same caution applies to a large range of other non-GLP-1-related peptides that are promoted well beyond the supporting human evidence and in the absence of adequate safety data.[8] Unapproved peptides are not included in the Australian Register of Therapeutic Goods and have not been evaluated by the TGA for safety, quality or effectiveness
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