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Conflict of interest Author JW was employed by Charles River Laboratory Edinburgh Ltd

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In vivo, circulating acetyl-L-carnitine concentration was increased 43% after oral acetyl-L-carnitine supplements of 2 g/day, indicating that acetyl-L-carnitine is absorbed at least partially without hydrolysis

We should not forget that the effect of the mutant MTHFR 677TT genotype is exacerbated under conditions of low folate intake/bioavailability, but can be counteracted by physiological levels of folate (Martnez-Fras, 2008)

doi:10.1016/j.xkme.2023.100704