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Sharma P, Kumar S
A meta-analysis of 11 RCTs in 601 PCOS women found that vitamin D co-supplementation significantly reduced fasting glucose and HOMA-IR, with the strongest effect at doses under 4,000 IU per day (agowska et al
These sex differences have biological plausibility because GLP-1 receptors are expressed in central appetite circuits and peripheral tissues whose signaling is modulated by estrogen and other sex steroids (Vigil et al., 2022
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