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With seven additional Phase 3 trials expected to read out in 2026, Retatrutide is positioning itself as potentially the most effective obesity medication ever developed
In one animal study, knock-down of GLP-1Rs in the brain neurons almost eliminated the effect of liraglutide, whereas knock-down of GLP-1Rs in the peripheral nervous system did not alter its efficacy significantly (185)
Recent studies have shown that GLP-1 use is associated with a reduction in cases of dementia among people with type 2 diabetes (something that's likely to also be true in a broader population of people at risk for dementia)
Food and Drug Administration concluded that this wasnt safe
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