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In ovarian pathology, ROS overload in follicular fluid first activates the ER stress sensor PERK, promoting phosphorylation of the eukaryotic translation initiation factor eIF2
Meanwhile, activation of the Keap1/Nrf2 pathway induced the expression of SOD, GSG, and CAT simultaneously, scavenged excessive free radicals and decreased the expression of GSSG, MDA, and LDH, and reduced oxidative stress injury
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"The role of glutathione S -transferase P in signaling pathways and S -glutathionylation in cancer"
