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Impact of pancreas Patients with obesity might also have damaged pancreatic islets
Current UK practice increasingly favours an individualised, risk-stratified approach rather than routine discontinuation for all patients
Tirzepatide is not indicated for type 1 diabetes and should not be used in combination with other GLP-1 receptor agonists or weight management medications
Lancet 394 (10193), 121130 (2019)
In preclinical and in-vitro models, reta peptide (retatrutide, GLP3-R) is studied as a triple-receptor agonist reference compound targeting GLP-1R, GIPR, and GCGR
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