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As mentioned earlier, pharmacological use of GLP-1 agonists is primarily taken to treat T2D and obesity, and they have impactful effects to achieve in desired results to regulate plasma glucose levels, they also reduce hunger and suppress daily calorie intake
Expression of PPAR is also found in hypothalamic nuclei that govern energy metabolism 24 , and viral-mediated overexpression of hypothalamic PPAR decreases food intake in diet-induced obese (DIO) mice 25
Moon, H
K., Samsom, M., Jones, K
Abstract Aims/hypothesis The insulinotropic hormone, glucagon-like peptide-1 (GLP-1), is rapidly degraded in vivo as a result of the combination of extensive enzymatic degradation and renal extraction
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