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While some preclinical research has explored potential immunomodulatory effects of GLP-1 receptor agonists, there is currently insufficient clinical evidence to establish this as a mechanism for systemic symptoms in patients taking tirzepatide

Year-to-date, the pharmas shares have slid more than 40%, with both investors and analysts expressing skepticism regarding the companys commercial execution for its semaglutide franchise

Long-term efficacy, safety, and tolerability of alirocumab in 8242 patients eligible for 3 to 5 years of placebo-controlled observation in the ODYSSEY OUTCOMES Trial

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Search keywords included GLP-1, GLP-1RA, neuro-ophthalmic conditions, incretin, anti-inflammatory, diabetic retinopathy, neurodegeneration, macular edema, NAION, semaglutide, and liraglutide. Articles found in the above search engines without any date restrictions were included in the review