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Three mechanistic domains that might influence BoNT-A durability were then modelled: Synaptic modulation via GLP-1-related cAMP/PKA mediated SNAP-25 phosphorylation Lean-mass decline altering diffusion/kinetic parameters Metabolic variability reflecting diabetic or rapid weight-loss phenotypes
GLP-1 / GLP-3 Receptor Agonists Incretin-mimetic peptides studied for glucose homeostasis, energy balance, and metabolic regulation
Back Tashko (2024) 'History of GLP-1: From Discovery to Revolutionary Treatment'
It is generally safe when used as prescribed, but may cause side effects like nausea or digestive discomfort
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