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Because the elimination half-life is approximately one week and steady-state exposure builds over 4 to 5 weeks of once-weekly administration, exposure declines slowly, which is why the labels specifically contemplate a prolonged period of observation and treatment rather than a short one

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A RECENT study has identified a potential link between the use of semaglutide, a glucagon-like peptide 1 receptor agonist (GLP-1 RA), and an increased risk of developing nonarteritic anterior ischemic optic neuropathy (NAION) in patients with type 2 diabetes (T2D) or those who are overweight or obese