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It was revealed that pretreatment with lixisenatide significantly suppressed elevation of inducible nitric oxide synthase (iNOS) and reversed the expression of endothelial nitric oxide synthase (eNOS) at the protein level and reduced mRNA of (NADPH oxidases 2) NOX2 in carotid arteries, which finally alleviated the endothelial dysfunction caused by ischemic/reperfusion (CI/R) in rats with diabetes more apparently than glimepiride (118)

These medications work by curbing appetite and slowing digestion, which helps reduce calorie intake and promote weight loss

Metformin is a first-line drug for treating type 2 diabetes associated with AMPK activation

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