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Stimulant laxatives (senna, bisacodyl): senna has better evidence in support of its use for (general) chronic constipation than bisacodyl, but neither has been specifically recommended for treating GLP-1 constipation
AEDs contribute to weight gain, and excess weight has been associated with a higher risk of drug-resistant epilepsy
If GLP-1 therapy is a good fit, we prescribe it and manage it properly
It manifests as localized fat accumulation and/or water retention, potentially accompanied by microcirculatory alterations
However, if accompanied by severe abdominal pain, persistent vomiting, bloody stools, or significant weight loss beyond expected therapeutic effects, medical evaluation is warranted to rule out other gastrointestinal conditions
