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Phentermine carries higher cardiovascular risks including elevated heart rate, increased blood pressure, and dependency potential as a Schedule IV controlled substance

In addition, alcohol is metabolized by alcohol dehydrogenase and cytochrome P450-2E1 (ADH and CYP2E1) enzymes found in the brain endothelial cells leading to the production of ROS, which is responsible for oxidative stress and production of neurodegenerative agents (2)

The chemical properties of semaglutide make it susceptible to degradation at higher temperatures

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