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GLP-1 originating from the gut has a very short circulating half-life of only 12 min due to its rapid inactivation by the enzyme dipeptidylpeptidase-4 (DPP-4) and subsequent clearance through the kidneys
GLP-1R/GIPR dual agonists like the aforementioned tirzepatide enhance glycemic control by increasing insulin secretion, suppressing glucagon, and slowing gastric emptying while potentially improving satiety via central mechanisms
Procedure day: Report to outpatient surgery if harvesting your own STEM cells via BMAC Anesthesia will be required, typically sedation with monitered anesthesia care but may vary Local anesthesia for comfort Your bone marrow aspirate is surgically harvested from the same involved lower extremity Bone marrow aspirate is spun and concentrated for potent stem cells and platelet rich plasma Image-guided injection into affected area Recovery: Rest and elevation for 48-72 hours Gradual return to activity over 4-6 weeks Full healing response develops over 3-6 months Follow-up appointments at 6 weeks, 3 months, and 6 months Success Rate: Clinical studies show 70-82% of patients with ankle osteoarthritis report significant pain reduction and improved function 6 months post-treatment
Like any medical treatment, GLP-1s are not without risks
