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In theory, the difference in the effects might be attributed to a limited set of upstream and downstream effector proteins in erythrocytes compared with nucleated cells [84]
Adipocyte hypoxia-inducible factor 2alpha suppresses atherosclerosis by promoting adipose ceramide catabolism
That means three things in practice
Based on the implication of redox imbalance and ferroptosis in DON pathology 22 , and GAs profile as an Nrf2 activator 27 with anti-ferroptotic potential 28 , we hypothesized that GA protects against DON toxicity by enhancing cellular antioxidant defenses via the Nrf2 pathway, thereby suppressing ferroptosis
Nuotio J, Laitinen TT, Sinaiko AR, et al
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