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Longer duration was also linked to increased occurrences of major adverse cardiovascular events (MACE), expanded MACE, and nephropathy events
Cardiovascular Risk Reduction# Recommendation : Semaglutide Reason : SELECT demonstrated 20% MACE reduction with semaglutide 2.4 mg in 17,604 patients
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(We use semaglutide 2.4 mg to describe the drug marketed as Wegovy independent of dose to distinguish it from other brands of semaglutide-containing products [i.e., Ozempic, Rybelsus] that have different indications and/or routes of administration.) Clinical trials in the Semaglutide Treatment Effect in People with Obesity (STEP) program have demonstrated the efficacy of semaglutide 2.4 mg in reducing weight in adults with obesity and overweight [9]
