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demonstrated that GLP-1 agonist administration could lead to an increase in neurogenesis in the hippocampus dentate gyrus region, and demonstrated an improvement in mood and cognitive function through the swim test in adult rodents (Isacson et al., 2011)

In -cells, GLP-1(936) activates GLP-1R, increasing cAMP and activating PKA and CREB to promote insulin secretion

Its plasma concentration decreases with age (200 ng/mL at age 20 vs