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Seek urgent care for severe weakness, unusual sleepiness, rapid breathing, persistent vomiting, abdominal pain, confusion, or fruity-smelling breath

This off-target binding is the likely contributor to its cortisol and ACTH co-secretion, as it stimulates the hypothalamic-pituitary-adrenal axis in addition to the GH axis

2009 Jan;276(1):58-75

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Semaglutide is a GLP-1 (glucagon-like peptide-1) receptor agonist, which means it mimics a naturally occurring hormone that helps regulate both blood sugar and appetite