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Semaglutide and tirzepatide are both effective medications for helping people lose weight
A 2022 study in Obesity (Santoro et al.) measured serum estradiol levels in women losing weight on GLP-1 agonists and found estrogen levels 40% to 60% higher than baseline during the first 12 weeks, then gradual normalization as weight loss decelerated
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The SURMOUNT-4 trial examined weight maintenance, showing that participants who continued tirzepatide after initial weight loss maintained and even extended their results, while those switched to placebo regained 14% of lost weight during the follow-up period
In controlled sleep research, DSIP has been associated with increased sleep pressure and improvements in sleep parameters vs placebo
