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It occurs when stomach acid or, occasionally, stomach content, flows back into the esophagus, the tube connecting the mouth and stomach
Bu, B., Ashwood, P., Harvey, D., King, I
Native human alpha-MSH is the 13-residue parent, Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH, with a methionine at position 4 that is the most oxidation-prone group in the molecule and an all-L backbone that peptidases cleave readily
I don't see many remaining critical issues in terms of patient safety
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