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Paradoxically, while angiogenesis is initiated to alleviate hypoxia, the resulting vasculature frequently fails to resolve oxygen deficiency, thereby creating a vicious cycle of persistent hypoxia and continued HIF activation (165)

LOW VITAMIN B12 AND LIPID METABOLISM: EVIDENCE FROM PRE-CLINICAL AND CLINICAL STUDIES Increase in body mass index-standard deviation score was associated with a decrease in vitamin B12 levels

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Abstract Metabolic dysfunction-associated steatotic liver disease (MASLD) is a highly prevalent chronic liver disease that can progress to end-stage conditions with life-threatening complications, but no pharmacologic therapy has been approved

But they cannot establish efficacy