Samoilov, M., Plyasunov, S
Seek medical attention if cold intolerance occurs with severe fatigue, hair loss, cognitive changes, unexplained weight changes, slow heart rate, or body temperature below 95F
Warning signs that warrant urgent medical attention include palpitations associated with: Chest pain or tightness Shortness of breath or difficulty breathing Dizziness, light-headedness, or fainting (syncope or pre-syncope) Severe fatigue or weakness Patients should be encouraged to keep a symptom diary , noting the frequency, duration, and context of palpitations (e.g., time of day, activity level, recent caffeine or alcohol intake)
Conservative dosing does not mean no risk
In SURPASS-3, Mounjaro lowered patient weight by 15 pounds (5 mg), 21 pounds (10 mg), and 25 pounds (15 mg) compared to a gain of 4 pounds with insulin degludec