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Note that in addition to canonical (barrier-related) functions, zonulin and occludin have other key, noncanonical functions that allow them namely to regulate epithelial apoptosis and proliferation and to facilitate viral entry (124)

Data availability The MD data generated in this study have been deposited in the Zenodo repository under the accession code 10963887

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Eprotirome appeared to be more liver-specific than sobetirome and did not cause myocardial off-target effects