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A boxed warning is the FDAs strongest safety alert, issued when a drug carries a serious or life-threatening risk
Calabrese et al., 2021
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and AstraZeneca PLC provide strong alternatives, focusing on expanding their respective portfolios of GLP-1 receptor agonists to treat type 2 diabetes and other related conditions
This may be related to gender-related pharmacokinetic differences (lower clearance of GLP-1RA in females) 41 and postmenopausal changes in gastrointestinal motility 42
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