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However, anecdotal reports suggest that semaglutide might be associated with NAION

The patients experienced a statistically significant improvement from baseline to the end of the observation in pain intensity on VAS (from 75.9 1.56 to 51.9 1.99

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Compared with the reference subject of 85 kg, a subject weighing 55 kg had on average a 40% increased semaglutide exposure and a 127 kg subject had a 27% lower semaglutide exposure

As emerging evidence builds, providers must balance potential benefits with safety concerns and patient-specific factors