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Diabetes Metab Rev 14:263283 Ashrafian H, Horowitz JD, Frenneaux MP (2007) Perhexiline
Extracellular matrix protein 1 promotes cell metastasis and glucose metabolism by inducing integrin beta4/FAK/SOX2/HIF-1alpha signaling pathway in gastric cancer
doi:10.1007/s40262-022-01140-3 188
Here are some symptoms of undermethylation to look out for: [22] Elevated homocysteine levels Depression Irritability Anxiety Multiple miscarriages Multiple chemical sensitivities Sensitivity to anesthetics Red face that lasts after exercising Allergies Being prone to addiction High libido Obsessive-compulsive disorder (OCD) Low pain threshold Headaches/migraines Digestive problems (such as IBS) Brain fog (especially after protein-rich meals) Insomnia High estrogen levels/estrogen dominance Low energy/fatigue Muscle pain Low levels of neurotransmitters (dopamine, norepinephrine, and serotonin) Heavy menstrual periods with blood clots Flakey skin rash under your nose* Lowered immunity* *Although I havent seen this in the research, its been an observation for me personally, as well as for a few clients, that difficulty fighting off viral infections as well as having a red rash under the nose, seems to correlate with poor methylation
PEGylated carboxyhemoglobin bovine (SANGUINATE): results of a phase I clinical trial
