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Many commercial preparations contain additional ingredients such as: Sorbitol or mannitol sugar alcohols used as sweeteners in some tablets that can cause osmotic diarrhoea when consumed in larger quantities, though the amounts in typical supplements are usually too small to cause symptoms alone [13] [14] Binding agents and fillers including lactose, which may cause symptoms in people with lactose intolerance, though tablet quantities are typically small Other additives various excipients that some individuals may be sensitive to The dose and frequency of supplementation may also influence tolerability
As noted by Kraus et al., Nature Medicine and Ng et al., Journal of Endocrinology , targeting both systemic metabolism and localized fat cell activity may enhance fat-loss outcomes beyond either approach alone
These symptoms often develop slowly and worsen over time
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