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For example, tranylcypromine and desipramine increase exon I, II, and IV (original III) mRNAs, fluoxetine treatment enhances activity of promoter II [88], whereas reboxetine increases activation of promoter IV [87]

This leads to higher concentrations of these feel-good peptides, potentially contributing to both the calming effects and the mild analgesic properties some users report

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The single human dataset for musculoskeletal use is a retrospective chart review of sixteen knee-pain patients who paid for intra-articular injections, with subjective improvement reported in fourteen and no control, no blinded assessment, and no objective imaging endpoint

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