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DPP-4 enzyme rapidly degrades active GLP-1, reducing its circulating half-life to just 2-3 minutes
Some researchers prefer morning injections because appetite suppression kicks in during the day when eating decisions are made
Further, the combination-therapy group had no changes in cortical ADC
Theoretically, combining serotonergic medications with GLP-1 agonists does not create serotonin syndrome risk, as GLP-1 agonists do not directly increase central serotonin
J Neurosci 31 , 39043913, (2011)
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