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Even if the amount of GLP-1 produced from probiotic-stimulated L cells is modest in terms of systemic blood levels, local activation of vagal afferents in the gut could still transmit meaningful satiety signals to the brain
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Boveris, A., Oshino, N
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Animal studies indicate dose-dependent effects, with toxic doses possibly affecting copper metabolism or interacting with embryonic development in hypersensitive models, warranting caution during pregnancy
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