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Hasanein P, Emamjomeh A
doi: 10.3389/fmed.2026.1770866 Received 18 December 2025 Revised 09 January 2026 Accepted 19 January 2026 Published 18 February 2026 Volume 13 - 2026 Edited by Anastasios Potiris, National and Kapodistrian University of Athens, Greece Reviewed by Xinghua Yu, Zhejiang University, China Konstantinos Louis, University General Hospital Attikon, Greece Updates Copyright 2026 Jagadesh and Sridharan
Beyond energy metabolism, NAD+ functions as an essential substrate for three classes of enzymes: sirtuins (class III histone deacetylases involved in epigenetic regulation), PARPs (poly-ADP-ribose polymerases involved in DNA repair), and CD38/157 (ectoenzymes regulating calcium signaling)
TB-500 is injected two times per week during loading and once weekly during maintenance
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