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Local IGF-1 is produced by many peripheral tissues in autocrine and paracrine fashion, including muscle, bone, and various other cell types
10.1080/10408398.2020.1865871 38 GwonM
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In vitro barrier models using Caco-2 cells (gut epithelium) or brain endothelial cells could be employed to test the hypothesis that microbiota metabolites, such as butyrateeither administered directly or derived from patient-derived fecal microbiota culturescan strengthen epithelial and endothelial barrier function and reduce oxidative stress [40]
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