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Most clinical guidelines and obesity specialists recommend GLP-1 medications as long-term or indefinite treatments for obesity similar to how blood pressure or cholesterol medications are used chronically

GLP-1 agonists and dual GLP-1/GIP agonists are the newest ones, but older drug classes like lipase inhibitors, phentermine, and combination medications may be appropriate in certain circumstances

What is Melanotan II

Summary: GLP-1 receptor agonists are not formally associated with leg cramps, but indirect mechanisms such as dehydration and electrolyte imbalances from gastrointestinal side effects may contribute to muscle cramping in some patients

If your current treatment isn't doing the trick, chat with your provider about alternative options