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Exenatide may promote differentiation of pancreatic ductal cells to a beta-cell phenotype in baboons without inducing pancreatitis, accumulation of parenchymal or periductal inflammatory cells, ductal hyperplasia, dysplastic lesions, or pancreatic intraepithelial neoplasia [26]

Now one of the most commonly prescribed medications, GLP-1s date back to 2005 with Byetta (exenatide), the first-ever GLP-1 derived from the venom of a Gila monster lizard

Researchers may use traditional Chinese medicines, western medicines, proprietary Chinese medicines, and other drugs for treatment or select inhibitors or agonists of specific proteins for intervention and even employ advanced means such as gene intervention

These medicines copy the effects of the natural GLP-1 hormone, which the body releases after eating

In the pancreas, these drugs stimulate insulin secretion in a glucose-dependent manner, meaning they promote insulin release only when blood sugar levels are elevated