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Importantly, unlike -adrenergic stimulationinduced increases in myocardial cAMP, which enhance contractility, GLP-1 showed negative inotropic effects in rodent cardiac myocytes, implicating a compartmentalized mechanism of cAMP production away from the contractile apparatus (53)

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Significant reductions in body weight can alter the volume of distribution and metabolic clearance of levothyroxine, potentially necessitating dose adjustments

Care Diabetes 10 , 156159 (2016)