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Metformin Metformin has a near-neutral effect on weight, with one meta-analysis finding no effect [164] and others finding small reductions in BMI, approximately of 0.77 kg/m (95%CI: 1.26, 0.27) compared to placebo after three months of treatment with 1500 mg/day in women with PCOS [165, 166]
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Gene-silencing nanoparticles targeting SLC7A11 have shown promise in reducing the activity of CAFs, which contribute to PDAC progression by creating a physical barrier to therapeutic agents [66]
10.3390/antiox11040756 33 KimJ
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