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In another study, the TRP-KYN pathway was one of the most significantly altered metabolic pathways in the CSF of patients with status epilepticus, with elevated levels of QA reflecting a more severe seizure state [100].The dysregulation of KP is not restricted to TLE
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The 2025 narrative review noted that despite the volume of preclinical work, well-controlled human trial data are scarce, and the regenerative findings should be interpreted accordingly (PMID 40789979)
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J Clin Invest 126:27212735
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