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Although some GLP-1RAs can cross the blood-brain barrier (BBB) and may exert neuroprotective effects 48 , the extent and precise mechanisms of their impact on neurodegenerative processes remain unclear

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Natural polymeric NPs such as chitosan, due to the presence of a cationic amine group, can electrostatically interact with bacterial negatively charged membrane lipid structure and increase the permeability by destabilizing phospholipids in the membrane

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Improving protein intake and ensuring adequate caloric intake (not extreme restriction) helps resolve it

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