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10.3389/fphys.2018.00477 Front Physiol

Association of Piriformospora indica with Arabidopsis thaliana roots represents a novel system to study beneficial plant-microbe interactions and involves early plant protein modifications in the endoplasmic reticulum and at the plasma membrane

Its considered a strong relative precaution, not necessarily an absolute contraindication for everyone

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Its important to listen to your body and adjust your intake if necessary, especially if youre already consuming other sources of caffeine throughout the day