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Separately, in the REDEFINE 4 head-to-head trial against tirzepatide, CagriSema produced approximately 20.2% body weight reduction at 84 weeks, compared with 23.6% for tirzepatide

Available as both an injectable and oral option, semaglutide mimics the hormone GLP-1, effectively reducing appetite and promoting sustained weight loss

Kwun and Lee, 2023)

Contraindications and Use Restrictions GLP-1 medications should not be used by individuals with a personal or family history of medullary thyroid carcinoma, Multiple Endocrine Neoplasia syndrome type 2, known hypersensitivity to semaglutide, or during pregnancy or breastfeeding

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