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Notably, the Phase I clinical data reveal that the most frequent treatment-related adverse events (TRAEs) were predominantly hematologic (e.g., neutropenia [86.8%], leukopenia [90.1%], thrombocytopenia [71.9%]) and gastrointestinal (e.g., nausea [61.2%], stomatitis [52.9%], vomiting [47.9%]), which are typical of topoisomerase I inhibitor-based ADCs and manageable with supportive care [96, 97]

According to this rule, drug molecules having more than five hydrogen bond donors, more than 10 hydrogen bond acceptor, logP more than five and molecular weight more 500 dalton are less likely to be orally active

CONTRAINDICATIONS BOOK NOW Active Cancer: Avoid use if you have active malignancy or are undergoing cancer treatment

International Journal of Cosmetic Science , 31(5), 327-345.