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A recent phase III trial testing exendin-4 did not show an improvement, which may be linked to the lack of insulin desensitization in the study participants
The peptide itself is a GLP-1 receptor agonist
However, it is still an investigational medicine, and important questions remain about its long-term safety, durability of weight loss and effectiveness across different patient groups
Activation of these receptors by GLP-1R agonists has been shown to confer protection against microvascular damage, particularly in models of diabetic retinopathy and stroke
Scientific References Frequently Asked Questions Can high vitamin B12 levels cause symptoms
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