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8,15 Serum holotranscobalamin level, which is reduced in vitamin B 12 deficiency, compared favorably with homocysteine and methylmalonic acid levels as a confirmatory test in one study, but further trials are needed before its widespread use for this purpose can be recommended

Very large individuals (over 100kg) might tolerate the higher end

But cost and insurance questions often get in the way

This selectivity is theoretically advantageous because it avoids the hyperglycemia, carpal tunnel syndrome, and insulin resistance associated with systemic GH therapy

A pharmacokinetic study in rats found that oral administration produced substantial plasma concentrations, with a maximum concentration of 2252 ng/mL and an elimination half-life of approximately 6.9 hours