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The main disadvantage of the cited meta-analysis is that all findings were driven by the inclusion of 1 large study evaluating the effect of DPP-IV inhibitors on IBD risk in 141,170 individuals whereas other 15 studies accounted for 57,234 individuals (Abrahami et al

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In human monocytes GLP-1 is strongly detectable, with waning after differentiation into macrophages (23)

This well-established importance underlies the role of vitamin B12 deficiency in mood imbalances, psychotic disorders, and neuronal health, particularly in elderly patients, where this deficiency is estimated to affect up to 40% of the population (25, 72)