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Patients focused on long-term metabolic health sometimes pair MOTS-c with GHK-Cu, a copper peptide that targets tissue repair, collagen production, and anti-aging at the cellular matrix level through a completely separate mechanism

One case in the dataset ran continuously for nine months without a reported break, representing the far end of observed behavior

By comparison, orlistat (Xenical) produced approximately 3-4 kg more weight loss than placebo over 12 weeks in its pivotal trials, and GLP-1 agonists produce 8-15 kg more than placebo

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However, three major reviews didnt show sufficient evidence to support this claim (14, 15, 16)