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this relationship seems to play a relatively minor role, as far as current research shows

Both treated and untreated Mmut p.L690Ins/p.L690Ins mice exhibited significantly elevated levels of both methylmalonic acid and MCA in liver and plasma compartments compared with Mmut WT/WT control mice

Phys Ther

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These pancreatic effects are complemented by improved peripheral insulin responsiveness in muscle tissue and lipid storage sites, facilitating glucose disposal and reducing systemic insulin resistance - a key driver of hepatic lipid accumulation and MASH progression [28,31]